EC Number   |
Protein Variants |
Reference |
|---|
   3.1.11.1 | A153V |
the mutation is associated with colorectal cancer and cancer of the small intestine |
750877 |
| 3.1.11.1 | D173A |
inactive mutant, structure in complex with Ca2+, overview |
714695 |
| 3.1.11.1 | D173A |
site-directed mutagenesis, the exo1-D173A mutant defective in nuclease activity is able to maintain crossing-over at wild-type levels in a number of genetic intervals. Exo1-D173A cells are able to maintain crossing-over despite reducedhDNAformation |
-, 714807 |
| 3.1.11.1 | D173A |
with either mutant D173A alone or both mutant D173A and BLM, nucleolytic degradation is undetectable. It competitively inhibits Exo1-BLM-mediated resection |
700958 |
| 3.1.11.1 | D319A |
does not alter the secondary structure significantly. 2-fold binding defect to the C terminus of ssDNA-binding protein relative to wild-type ExoI |
700988 |
| 3.1.11.1 | D368A |
the exonuclease-deficient mutant is drastically impaired for 3'-to-5' exonuclease activity, with no activity detected even at high enzyme-to-DNA substrate ratios |
751429 |
| 3.1.11.1 | D405A |
mutant enzyme loses 99.8% of DNA polymerizing activity and 90% of 3'->5' exonucleolytic activity |
723691 |
| 3.1.11.1 | D405E |
mutant enzyme loses 95.8% of DNA polymerizing activity and 90% of 3'->5' exonucleolytic activity |
723691 |
| 3.1.11.1 | DELTAH672-S775 |
mutant enzyme loses 99% of DNA polymerizing activity and 97% of 3'->5' exonucleolytic activity |
723691 |
| 3.1.11.1 | DELTAL717-S775 |
mutant enzyme loses 97% of DNA polymerizing activity and 97% of 3'->5' exonucleolytic activity |
723691 |
