EC Number |
Protein Variants |
Reference |
---|
3.1.1.53 | A385T |
naturally occuring mutation |
730718 |
3.1.1.53 | A394T |
naturally occuring mutation |
730718 |
3.1.1.53 | A467V |
naturally occuring mutation from patients with anti-PIT-1 antibody syndrome. The mutation occurs in a heterozygous state in all the patients with anti-PIT-1 antibody syndrome, and in 6% of control subjects, the prevalence is significantly increased in the patients |
729642 |
3.1.1.53 | A467V |
naturally occuring mutation, the enzyme shows over 110% catalytic activity compared to the wild-type enzyme. The mutant is secreted upon overexpression |
730718 |
3.1.1.53 | C196F |
naturally occuring mutation, the mutant shows highly reduced catalytic activity compared with the wild-type enzyme |
730718 |
3.1.1.53 | C443R |
naturally occuring mutation |
730718 |
3.1.1.53 | E26A |
site-directed mutagenesis, the mutant shows highly reduced activity compared to the wild-type NanS |
716859 |
3.1.1.53 | F211A |
abrogated ligand recognition and binding |
700987 |
3.1.1.53 | F404S |
naturally occuring mutation |
730718 |
3.1.1.53 | G419E |
naturally occuring mutation |
730718 |