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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20E99A active site mutant 739642
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20H266Q missense mutation of Tpst2, devoid of activity, in the highly conserved region of the gene leads to the autosomal recessive, fetal-onset, severe thyroid hypoplasia phenotype related to TSH hyporesponsiveness in growth-retarded mice, the mutant enzyme shows unaltered subcellular localization, overview 676006
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20K158A active site mutant 739642
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20more conjugation of protein, e.g. the receptor-binding nontoxic B-subunit of Shiga toxin, with N-carbamoyl-succinate-modified peptides, method overview 702490
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20more consruction of truncation mutants lacking the cytosolic or the transmembrane domain, the first are not affected in their subcellular localization in the Golgi compartment, the latter are mislocated in the cytosol, overview 675396
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20more generation of homozygous and heterozygous TPST-1 and/or TPST-2 knockout mutant mice. Disruption of one allele at the TPST-1 locus has no significant effect, and TPST-1+/- mice appear normal, have unaltered fertility and growth curves. TPST-1 -/- mice show reduced postnatal body weight. Disruption of the TPST-2 gene also causes no significant effect in TPST-2+/- mice, but TPST-2-/- mice also show reduced postnatal body weight like TPST-1 -/-mice, but reached normal body weight at 10 weeks of age. The most significant difference between TPST-1 -/- and TPST-2 -/- is the reduced fertility of TPST-2 knockout mice 705836
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20more generation of isozyme TPST-2 deficient growth-retarded mutant mice, phenotype, overview 705417
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20more generation of Tpst1 and Tpst2 double knock-out mice 674717
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20more generation of Tpst1 and Tpst2 double knock-out mice, certain sperm/epididymal proteins are undersulfated in Tpst2-/- mice 674717
Display the word mapDisplay the reaction diagram Show all sequences 2.8.2.20more isozymes TPST-1 and TPSt-2, generation of single and double knockout mice. Double knockout mice completely lack the ability to sulfate peptidyltyrosine, Tpst2-/- mice show primary hypothyroidism, but that Tpst1-/- mice are euthyroid, phenotypes, overview 703831
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