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Results 1 - 8 of 8
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86K160E mutation dramatically reduces enzyme activity but only slightly reduces DNA binding 738356
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86K240E mutation dramatically reduces DNA binding, mutant still exhibits some catalytic activity 738356
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86more generation of truncated cGAS161 mutant, binding kinetics with dinuclotides and inhibitors, overview. Analysis of structures of the N-terminal truncation of cGAS starting at residue 161 (cGAS161)22 in complex with five cyclic dinucleotides: 2',2'-cGAMP, 2',3'-cGAMP, 3',3'-cGAMP, 3',3'-cdIMP, and 3',3'-cdUMP, and the linear 2',5'-GpAp dinucleotide, interaction analysis. No interaction between Asp227 and 3',3'-cdUMP or 2',2'-cGAMP. 2',3'-cGAMP or 3',3'-cGAMP have an amino group interacting with Asp319 instead of Asp227. In four of these structures, cGAS assumes the beta-pseudo-active conformation 762338
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86more mutation of Sp1 and CREB binding sites in the cGAS promoter region leads to an apparent reduction of the cGAS promoter activity. Overexpression of Sp1 and CREB can enhance promoter activity, whereas knockdown of endogenous Sp1 and CREB markedly restrains the cGAS promoter activity. Transcription factors Sp1 and CREB regulate the transcription of the cGAS gene 760853
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86R158E mutation dramatically reduces enzyme activity but only slightly reduces DNA binding 738356
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86R161E mutation dramatically reduces enzyme activity but only slightly reduces DNA binding 738356
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86R222E mutation dramatically reduces DNA binding, mutant still exhibits some catalytic activity 738356
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86S165E mutation dramatically reduces enzyme activity but only slightly reduces DNA binding 738356
Results 1 - 8 of 8
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