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Results 1 - 10 of 244 > >>
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7A329A not meaningfully associated with breast cancer risk; more likely to respond to Pt-based chemotherapy 761958
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7A408S A408S mutation results in a significant increase in both dNTP binding affinity and fidelity, kcat/Km for dATP is about 45% compared to the wild-type enzyme, D215A mutation results in inactivation of 3'-5'-exonuclease activity 721612
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7A467T naturally occuring mutation, the mutation is the most common POLG mutation and has been found to be associated with all of the disease symptoms analyzed. The A467T pol gamma possesses only 4% of the wild-type DNA polymerase activity and is compromised for its ability to interact with the p55 accessory subunit 723108
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7A471V moderate decrease in activity 761958
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7A957S naturally occuring mutation, involved in autosomal dominant progressive external ophthalmoplegia, the mutation is associated with motiif B in the active site 723108
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7D10A retains polymerase activity, reduced exonuclease activity, changes in dependency on metal activation of exonuclease activity 643653
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7D111A 94% loss of DNA polymerase activity 726027
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7D1122A loss of polymerization activity 722619
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7D1122E mutant enzyme with reduced polymerization activity, polymerization activity is 15% compared to wild-type activity, 3'-5' exonuclease activity remains, the mutant has lower Mg2+ affinity than does the wild-type 722619
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.7D1124A loss of polymerization activity 722619
Results 1 - 10 of 244 > >>