EC Number   |
Protein Variants |
Reference |
|---|
   2.7.4.24 | D332A |
2.4-4fold larger net formation of 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate, but mutation nearly completely impaires its hydrolysis |
761474 |
| 2.7.4.24 | D332A |
catalytically inactive mutant of isozyme PPIP5K1 |
698738 |
| 2.7.4.24 | E192G |
site-directed mutagenesis |
738042 |
| 2.7.4.24 | E192Q |
site-directed mutagenesis |
738042 |
| 2.7.4.24 | K103A |
site-directed mutagenesis |
738042 |
| 2.7.4.24 | K213A |
site-directed mutagenesis |
738042 |
| 2.7.4.24 | K248A |
the mutant shows a reduction in 1D-myo-inositol hexakisphosphate-stimulated ATPase activity of isofom PPIP5K2. The mutant shows a significant reduction in the rate of 1D-myo-inositol phosphate-independent ATPase activity of isofom PPIP5K2 |
721882 |
| 2.7.4.24 | K54A |
site-directed mutagenesis |
738042 |
| 2.7.4.24 | more |
construction of an N-terminally truncated mutant PPIP5K2KD comprising residues 41-366 |
738042 |
| 2.7.4.24 | more |
construction of full-length recombinant human GSTIP6K1, plus either GST fusion constructs comprising residues 1-387 of the human VIP1/PPIP5K1 kinase domain or residues 1-535 of the ScVip1 kinase domain |
717780 |
