Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search Protein Variants

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 10 of 55 > >>
download as CSV
download all results as CSV
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11C199A inactive 739224
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11C199A the mutant of the catalytic alpha-subunit in the holoenzyme leads to insensitivity towards H2O2 693043
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11D170A site-directed mutagenesis of the regulatory subunit RIalpha, the mutation selectively reduces the negative cooperativity between the cAMP- and C-recognition sites, i.e. the KD for the regulatory-catalytic subunit complex in the presence of cAMP is reduced by more than 12fold, without significantly compromising the high affinity of the regulatory subunit for both binding partners, conformational shifts upon mutation, and physiological implications of the dual functionality of the D170A mutant, overview 677061
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11D328A site-directed mutagenesis of the catalytic subunit, mutant shows decreased interaction with the regulatory RI subunit 662378
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11D328A/K72H site-directed mutagenesis of the catalytic subunit, inactive mutant showing decreased interaction with the regulatory RII subunit 662378
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11E230Q site-directed mutagenesis of the catalytic subunit, the mutation affects the local structure of the the F-to-G helix loop and asp241, and the binding of protein kinase inhibitor PKI, the mutant protein can only be crystallizes as apoenzyme 672647
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11E230Q site-directed mutagenesis, mutation of an acidic residue from the cluster around the active site of the catalytic subunit C, E230 forms the salt bridge required for interaction with the substrate, mutant shows decreased substrate recognition, phosphorylation degree, and activity compared to the wild-type subunit C, mutant has an open conformation and does not bind ligands like MgATP2- or IP20 inhibitor 663344
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11I204A site-directed mutagenesis, subunit RIalpha residue mutation, slightly impaired activation of subunit C, mutant show a slightly lower melting temperature compared to the wild-type subunit RIalpha 663349
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11K336A/H338A i.e. Tpk1K336A/H338A, site-directed mutagenesis, a catalytically inactive PKA variant, that exhibits a stable binding to the substrate 673866
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.11K72A site-directed mutagenesis, inactive unphosphorylated mutant 662452
Results 1 - 10 of 55 > >>
download as CSV
download all results as CSV