EC Number   |
Protein Variants |
Reference |
|---|
   2.7.10.2 | A356N |
the mutation increases enzyme activity |
737723 |
| 2.7.10.2 | A433T |
naturally occuring mutation in kinase ABL1 of chronic myeloid leukemia patients |
672787 |
| 2.7.10.2 | C616Y |
the JAK2 mutation is associated with polycythemia vera |
705448 |
| 2.7.10.2 | C618R |
the JAK2 mutation is associated with polycythemia vera |
705448 |
| 2.7.10.2 | D276A |
site-directed mutagenesis, reduced activity with substrates poly(Glu4-Tyr) and [kdSrc kinase]-L-tyrosine compared to the wild-type enzyme |
663196 |
| 2.7.10.2 | D276G |
naturally occuring mutation in kinase ABL1 of chronic myeloid leukemia patients |
672787 |
| 2.7.10.2 | D332A |
site-directed mutagenesis of Csk in the DFG motif in front of the activation loop leads to complete loss of kinase activity |
662138 |
| 2.7.10.2 | D344A |
site-directed mutagenesis of Csk in the activation loop, mutant shows slightly increased activity with kdSrc and slightly reduced activity with poly(Glu4-Tyr) as substrates compared to the wild-type enzyme |
662138 |
| 2.7.10.2 | D382N |
site-directed mutagenesis, catalytically inactive mutant |
675920 |
| 2.7.10.2 | D518A |
site-directed mutagenesis of Src, the mutant enzyme shows reduced interaction with the Csk and reduced inactivation by Csk |
674767 |
