EC Number   |
Protein Variants |
Reference |
|---|
    2.7.1.15 | A13/103/116V |
mutant shows no interaction with topoisomerase I. Mutant only partially retains its ability to inhibit the activity of topoisomerase I even at high protein concentrations. Topoisomerase I does not significantly stimulate the activity of the mutant protein |
713968 |
| 2.7.1.15 | E202L |
mutation in NXXE motif, increase in the Km for MgATP of 52fold, and a decrease in the kcat value of around 200fold |
737810 |
| 2.7.1.15 | M10N |
70 fold higher KM for deoxyribose but only 2 fold increased KM for ribose |
641007 |
| 2.7.1.15 | N199L |
mutation in NXXE motif, increase in the Km for MgATP- by about 68fold, a decrease in the kcat between 573- and 1036fold and almost no change in the Km for D-ribose. No substrate inhibition by D-ribose |
737810 |
| 2.7.1.15 | S11N/A14V |
mutant shows no interaction with topoisomerase I |
713968 |
| 2.7.1.15 | S11N/A14V |
mutant shows no interaction with topoisomerase I. Mutant only partially retains its ability to inhibit the activity of topoisomerase I even at high protein concentrations. Topoisomerase I does not significantly stimulate the activity of the mutant protein |
713968 |
