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Results 1 - 8 of 8
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149D271K inactive 739535
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149D272K kinase-dead mutant 760061
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149D280K inactive 737638
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149E300D Site-directed mutagenesis is performed on the human Type IIbeta PIPkin cloned into pEGFP-C1 using the QuikChange mutagenesis method, to introduce an Glu300Asp amino acid substitution into the human nuclear localisation sequence producing the equivalent chicken sequence. 686033
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149more isozymes PIPKalpha and PIP4Kbeta inactivation by specific RNAi. Overexpression of PIP4Kalpha leads to a dramatic increase in PIP4K activity, that is not present when wild-type PIP4Kbeta kinase is expressed 721525
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149more knockdown of both isozymes, enzyme activity associated with kinase-inactive Myc-PIP4Kbeta is reduced to 24% compared with that associated with the active Myc-PIP4Kbeta 721525
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149more PIPKIIbeta knockdown 721493
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149N165I the mutation in isoform PI5P4Kgamma leads to resistance to inhibitor NIH-12848 758613
Results 1 - 8 of 8
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