EC Number |
Protein Variants |
Reference |
---|
2.7.1.148 | A382T |
naturally occuring mutation, neutral |
-, 762094 |
2.7.1.148 | D152A |
inactive mutant enzyme |
672138 |
2.7.1.148 | G402R |
naturally occuring mutation, neutral |
-, 762094 |
2.7.1.148 | K492T |
naturally occuring mutation, neutral |
-, 762094 |
2.7.1.148 | L405Q |
naturally occuring mutation, neutral |
762094 |
2.7.1.148 | more |
two non-synonymous mutations at codons 382 (A->T) and 492 (K->T) are found in all the isolates of Delhi, Chennai, Nadiad, Sonapur Goa, and Mangaluru. Apart from these, two more mutations are observed in all the isolates of Goa and Mangaluru namely one substitution at codon 351(T->M) and another synonymous mutation at codon 344 (S) TCT->TCC. In Rourkela which is one of the highly malaria endemic and isolated tribal regions of India, four non-synonymous mutations at codons 336 (R->S), 351 (T->M), 402 (G->R) and 405 (L->Q) are detected in all isolates. Domain architecture and mutation mapping, overview |
-, 762094 |
2.7.1.148 | R336S |
naturally occuring mutation, neutral |
762094 |
2.7.1.148 | T351M |
naturally occuring mutation, neutral |
-, 762094 |