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Results 1 - 10 of 47 > >>
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137C838C/I848A site-directed mutagenesis, 10% activity compared to the wild-type enzyme 661328
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137C838I/I848A site-directed mutagenesis, below 10% activity compared to the wild-type enzyme 661328
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137C838L/I848A site-directed mutagenesis, highly reduced activity, 0.1% compared to the wild-type enzyme 661328
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137D2243E site-directed mutagenesis, no functional complementation of a yeast enzyme-knockout mutant strain 661328
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137D743N kinase-dead catalytic loop mutant 722120
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137D749E site-directed mutagenesis, no functional complementation of a yeast enzyme-knockout mutant strain 661328
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137E545K a dominant activating mutation of the catalytic subunit PIK3CA that is prevalent in breast cancer and confers resistance to lapatinib, lapatinib effectively inhibits the transactivation of EGFR and HER2 by IGF-I signaling 707976
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137G373R naturally occuring mutation in gene PIK3R2 involved in bilateral perisylvian polymicrogyria 738948
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137H1047R a dominant activating mutation of the catalytic subunit PIK3CA that is prevalent in breast cancer and confers resistance to lapatinib, lapatinib effectively inhibits the transactivation of EGFR and HER2 by IGF-I signaling 707976
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.137H1047R HCT-116 cells are heterozygous for gain of function mutant PIK3CA catalytic subunit 709003
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