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2.6.99.2
synthesis
engineering of a Bacillus subtilis strain that forms significant amounts of pyridoxine via a non-native deoxyxylulose 5'-phosphate-(DXP)-dependent vitamin B6 pathway. The pathway consists of the 4-hydroxy-L-threonine-phosphate dehydrogenase PdxA, the pyridoxine 5'-phosphate synthase PdxJ and the native DXP synthase, Dxs. Bacteria are adapted to tolerate the antimetabolite 4-HO-Thro in order to allow feeding of high amounts of 4-hydroxy-threonine (4-HO-Thr) that can be converted to pyridoxine. The adapted bacteria produce 2834 mg/l pyridoxine from 4-HO-Thr while the wild-type parent produced 12 mg/l pyridoxine. Identification of a better combination of pdxA and pdxJ alleles results in production of 65 mg/l pyridoxine
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