EC Number   |
Protein Variants |
Reference |
|---|
   2.4.1.92 | C9A |
acylatable cysteine residue, which is critical for homodimerisation |
756002 |
| 2.4.1.92 | D356A/D356N |
variation of DXD motif, activity almost completely lost |
489591 |
| 2.4.1.92 | D356E |
variation of DXD motif, weak activity |
489591 |
| 2.4.1.92 | D356N/D357N/D358N |
variation of DXD motif, activity almost completely lost, no alteration in nucleotide binding |
489591 |
| 2.4.1.92 | D357N |
variation of DXD motif, weak activity |
489591 |
| 2.4.1.92 | D358A/D358N |
variation of DXD motif, activity almost completely lost |
489591 |
| 2.4.1.92 | I285Y |
site-directed mutagenesis, mutation of the residue to the human analogue results in change of substrate specificity from a beta4GalNAc-T1 to a beta4Gal-T1 by reducing its N-acetylgalactosaminyltransferase activity by nearly 1000fold, fold, while enhancing its galactosyltransferase activity by 80fold, overview |
675421 |
| 2.4.1.92 | more |
- |
489587, 489589 |
| 2.4.1.92 | more |
3 different epitope-tagged forms of enzyme, enzyme is homodimer and has disulfide bonds, is localized to Golgi |
489585 |
| 2.4.1.92 | more |
beta4GalNAcTA null mutant larvae show frequent backward crawling, reductions in nerve terminal bouton number, decreased spontaneous transmitter release frequency, and short, wide, hypercontracted muscles with low calcium content, indicating a role for this enzyme in the neuromuscular system |
673868 |
