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Results 1 - 6 of 6
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.370more association between recombinant HA3-tagged Csg2p and His6-myc-tagged Csg1p. The N-terminally truncated Csg2p retains the Csg1p-interacting site. The small amounts of M(IP)2C-B'/B and MIPC-C observed in the DELTAcsg2 cells are completely lacking after the introduction of the DELTAcsg1 mutation. The DELTAcsg2 mutant, as well as the DELTAcsg1/DELTAcsh1 double mutant, is highly sensitive to Ca2+ and does not grow on the YPD plate medium. Overexpression of Csg1p suppresses the Ca2+-sensitive phenotype of a csg2 mutant, but in the inverse experiment, overexpression of Csg2p does not suppress the Ca2+-sensitivity of a csg1 mutant -, 759459
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.370more generation of csg1 and csg2 mutants, phenotypes, overview. The csg1DELTA strain (689DELTAcsg1) is constructed by disrupting CSG1 in DBY689 (MATa ura3-52 leu2). The isogenic csg2D (689Dcsg2) and ccc2D (689Dccc2) strains are constructed by transforming DBY689 with the CSG2- or CCC2-disrupting constructs. Cu2+ reverses the Ca2+ sensitivity of csg1 mutant cells. Kinetics of Ca2+-induced cell death, in both csg1 and csg2 mutants, Ca2+ accumulation begins after a delay of about 30 min following addition of 10 mM Ca2+. This overaccumulation phenotype is specific for Ca2+, since Sr2+ accumulation in the csg1 and csg2 mutant cells is comparable to Sr2+ accumulation by wild-type cells. Calcineurin, calmodulin and phospholipase C do not mediate the Ca2+-induced death of the csg mutants -, 759777
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.370more the DELTAcsg1/DELTAcsh1 double mutant is highly sensitive to Ca2+ and does not grow on the YPD plate medium -, 759459
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.370N247Q site-directed mutagenesis, N-glycosylation of the mutant is reduced compared to the wild-type enzyme -, 759463
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.370N51Q site-directed mutagenesis, N-glycosylation of the mutant is reduced compared to the wild-type enzyme -, 759463
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.370N51Q/N247Q site-directed mutagenesis, N-glycosylation of the mutant is reduced compared to the wild-type enzyme -, 759463
Results 1 - 6 of 6
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