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EC Number	Protein Variants	Commentary	Reference
2.4.1.145	more	establishment of a choriocarcinoma cell line with GnT-IVa overexpression (Jar-GnT4a), and examination of its malignant potential and target proteins for GnT-IVa glycosylation. GnT-IVa overexpression increases the cell migration and invasion (2.5 and 1.4fold) as well as the ability to adhere to the extracellular matrix (ECM) components, including fibronectin and collagen type I and IV. The tumour formation potential of Jar-GnT4a in mice is significantly higher than that of control, and the cumulative survival rate of mice with Jar-GnT4a is relatively lower than those with control. Immunoprecipitation studies show that beta1,4GlcNAc branches of N-glycans on integrin beta1 in choriocarcinoma cells are increased by GnT-IVa overexpression	759880
2.4.1.145	more	knockdown of GnT-IVa in 1668 cells and HepG2 cells by transfection with GnT-IVa shRNA. The level of NA3Fb decreases and M8 increases in knockdown GnT-IVa/1668 cells compared with GnT-IVa/NC after 48 h transfection. The scratch healing rates of the GnT-IVa/1668 group decreases more than the GnT-IVa/NC group. High expression of GnT-IVa leads to a higher level of NA3Fb in the HCC cell surface, and the downregulation of GnT-IVa may modulate cell invasion and migration through NA3Fb glycan	737252

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Release 2023.1 (January 2023)