EC Number   |
Protein Variants |
Reference |
|---|
   2.3.1.45 | C88F |
naturally occuring polymorphism |
703889 |
| 2.3.1.45 | F88C |
single nucleotide polymorphism, associated with variant group B streptococcal O-acetylation phenotype, overview |
674531 |
| 2.3.1.45 | K123A |
single amino acid substitution in the active site ablates the O-acetyltransferase activity |
703889 |
| 2.3.1.45 | K123A |
site-directed mutagenesis, complementation of the COH1DELTANeuD mutant with the K123A mutant of NeuD restores sialylation but not O-acetylation |
674531 |
| 2.3.1.45 | more |
a transgenic mouse where O-acetylated GD3 is absent, shows a disruption in organogenesis, suggesting a role for O-acetylated GD3 in cellular differentiation |
677235 |
| 2.3.1.45 | more |
CASD1 knockout abolishes Sia O-acetylation in HAP1 cells. Transfection with CASD1 cDNA, but not empty vector, results in successful complementation of the loss-of-function defect and restored 9-O-acetylation of Golgi-localized sialoglycotopes |
736875 |
| 2.3.1.45 | more |
construction of an enzyme-deficient mutant strain DELTANeuD by allelic replacement mutagenesis, the mutant is functionally complemented by the enzyme from Escherichia coli K1, encoded by gene neuD, the mutant is also analyzed for complementation by the streptococcal K123A mutant, the NeuD-K123A plasmid restores sialic acid biosynthesis to the DELTANeuD mutant, but not the O-acetylation of Neu5Ac |
674531 |
| 2.3.1.45 | S94A |
site-directed mutagenesis, inactive mutant |
736875 |
