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EC Number Protein Variants Commentary Reference
Display the reaction diagram Show all sequences 2.3.1.291H220A/H221A complete loss of activity 754101
Display the reaction diagram Show all sequences 2.3.1.291more a mutant based on the backbone of CerS5 (which generates C16-ceramide), containing an 11-residue sequence of a loop located between the last two putative transmembrane domainsfrom CerS2 (which generates C22-C24-ceramides), is altered such that it generates C22-C24 and other ceramides. The mutant generates C22:0-ceramide and C16:0-ceramide to a similar extent but also generates C18:0-, C20:0-, and C24:1-ceramides 757217
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