Refine search

Search Protein Variants

Search term:

Results 1 - 6 of 6

download as CSV

download all results as CSV

EC Number	Protein Variants	Commentary	Reference
2.3.1.256	G149A	inactive	-, 740649
2.3.1.256	more	identification of a splice variant of human NAA30, which encodes a truncated protein named Naa30288. DNA sequencing reveals that the 900 bp product derived from alternative splicing results in a 222 bp deletion from the 3' end of exon 1 (c.550_771del). The truncated splice variant (867 bp) is otherwise identical to NAA30. Splicing NAA30_v2 translates into a truncated isoform (p.Val184_Leu257del) consisting of 288 amino acids (Naa30288). The splice variant is abundantly present in thyroid cancer tissues and in several different human cancer cell lines. Naa30288 localizes predominantly to the nucleus, as opposed to annotated Naa30 which has a cytoplasmic localization. Naa30288 is missing elements of the GNAT fold. Full-length Naa30 acetylates the classical NatC substrate peptide MLGTG in vitro, whereas no significant NAT activity is detected for Naa3028. Naa30288 appears to be enzymatically inactive. Overexpression of full-length Naa30362 increases cell viability via inhibition of apoptosis. In contrast, Naa30288 does not exert an anti-apoptotic effect	756860
2.3.1.256	more	siRNA-mediated knockdown of hNAA30 gene expression in HeLa and CAL-62 cells, phenotypes, detailed overview	756225
2.3.1.256	N123A	inactive	-, 740649
2.3.1.256	Y130A	inactive	-, 740649
2.3.1.256	Y144A	inactive	-, 740649

Results 1 - 6 of 6

download as CSV

download all results as CSV

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)