EC Number   |
Protein Variants |
Reference |
|---|
   2.1.2.9 | A172L |
site-directed mutagenesis, the mutation causes a 6fold decrease in enzyme activity compared to wild-type, the Vmax/Km of the mutant is about 4fold lower than that of the wild-type enzyme |
736461 |
| 2.1.2.9 | A172S |
site-directed mutagenesis, the mutation does not significantly affect the enzyme activity |
736461 |
| 2.1.2.9 | A55T |
no suppressor mutation |
-, 485810 |
| 2.1.2.9 | A59V |
the mutation causing substantially decreased enzyme activity is associated with selective vulnerability of the visual pathway and a mild neurological phenotype of Leigh syndrome. The missense mutation destabilizes the protein |
757809 |
| 2.1.2.9 | A89L |
site-directed mutagenesis, the Vmax/Km of the mutant is about 144fold lower than that of the wild-type enzyme |
736461 |
| 2.1.2.9 | A89S |
site-directed mutagenesis, the mutation does not significantly affect the enzyme activity |
736461 |
| 2.1.2.9 | D145A |
mutant enzyme with drastically reduced activity |
485814 |
| 2.1.2.9 | D145E |
mutant enzyme with 881fold reduced formylation rate, kinetic parameters |
485814 |
| 2.1.2.9 | D145N |
mutant enzyme with 4031fold reduced formylation rate, kinetic parameters |
485814 |
| 2.1.2.9 | del833 |
inactivated methionyl-tRNA formyltransferase |
701743 |
