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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8C314T PCR reaction-restriction fragment length polymorphism assay is used to identify the polymorphism of the point mutation C314T of HNMT gene of 498 Chinese patients with duodenal ulcer and 151 healthy individuals. In normal controls, the allele frequency of HNMT T314 is 3.3%, which is significantly lower than American Caucasians. The HNMT T314 allele is detected in 3.5% of the duodenal ulcer patients. In cases and controls, the frequency of C/C genotypes are 93.0% and 93.4%, respectively. The HNMT T/T genotype is not found in this population. No significant differences is seen in both genotype frequencies and allele frequencies between duodenal ulcer groups and controls 686166
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8L208D mutant is severely compromised in its stability 756090
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8L208F 21% of wild-type activtiy, Michaelis-Menten parameters for SAM and histamine similar to wild-type 756090
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8L208H mutant is severely compromised in its stability 756090
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8L208K substantial loss of enzymatic activity and binding affinity for histamine 756090
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8L208N mutant is severely compromised in its stability 756090
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8L208R substantial loss of enzymatic activity and binding affinity for histamine 756090
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8L208T mutant is severely compromised in its stability 756090
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8L208V 48% of wild-type activity, Michaelis-Menten parameters for SAM and histamine similar to wild-type 756090
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.8more subcutaneous injection of amodiaquine in mice with propionibacterium acnes-primed and lipopolysaccharide (LPS)-induced hepatitis significantly increases the histamine levels in the liver in comparison to saline treated mice. Pretreatment with amodiaquine also improves the survival rate of the hepatitis mice, and this improvement is partially associated with the decrease in serum levels of aspartate aminotransferase and alanine aminotransferase. Amodiaquine partially suppresses increases of tumor necrosis factor (TNF)-alpha in the serum and TNF-alpha mRNA expression in the liver 686550
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