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EC Number
Protein Variants
Commentary
Reference
2.1.1.34
D180A
42% of wild-type activity
734227
2.1.1.34
D190A
5% of wild-type activity
734227
2.1.1.34
E124A
13fold increase in Km-value
663410
2.1.1.34
E124A
extensive structural alterations compared to wild-type, marked decrease in activity
662326
2.1.1.34
E124D
small increase in Km-value
662326
2.1.1.34
E124Q
no enzymic activity
662326
2.1.1.34
E182A
29% of wild-type activity
734227
2.1.1.34
H34A
no change of affinity for S-adenosyl-L-methionine and tRNA
674692
2.1.1.34
H71A
has increased affinity for S-adenosyl-L-methionine, decreased affinity for tRNA
674692
2.1.1.34
I142A
kinetic parameters comparable to wild-type
663410
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