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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C118A inactive 734031
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C118A loss of tRNA methylation activity 758141
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C118A mutant is unable to resolve a covalent protein/RNA intermediate during catalysis and becomes cross-linked to the nucleic acid 758463
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C118A site-directed mutagenesis, analysis of the structure of a key intermediate in the RlmN reaction, in which a C118A variant of the protein is cross-linked to a tRNAGlu substrate 758463
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C118S inactive 734031
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C125A inactive mutant enzyme 704203
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C129A inactive mutant enzyme 704203
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C132A inactive mutant enzyme 704203
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C338A the mutant binds S-adenosyl-L-methionine with wild type affinity, while oxidation of the [4Fe-4S] cluster is not observed 735095
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.192C363A mutation in putative metyl-binding residue, substitution alters iron-sulfur cluster stability. Mutant exhibits negligible activity 756062
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