EC Number   |
Protein Variants |
Reference |
|---|
   1.14.99.66 | K661A |
enzymatically dead mutant of BHC110 |
754723 |
| 1.14.99.66 | K661A |
inactive mutant |
700154 |
| 1.14.99.66 | K661A |
site-directed mutagenesis, inactive mutant |
697909 |
| 1.14.99.66 | K667A |
point mutation in the amine oxidase domain, inactive mutant |
700397 |
| 1.14.99.66 | more |
Aof1 hetero- or homozygous mutants, phenotypes, overview. Oocytes from KDM1B-deficient females show a substantial increase in H3K4 methylation and fail to set up the DNA methylation marks at four out of seven imprinted genes examined. KDM1B deficiency results in H3K4me2 elevation in oocytes and maternal-effect embryonic lethality |
700397 |
| 1.14.99.66 | more |
construction of an enzyme mutant with a deletion of the NH2-terminal 184 amino acid residues (DELTA184 LSD1) |
753296 |
| 1.14.99.66 | more |
construction of two N-terminally truncated mutants, DELTA25 and DELTA257 |
698910 |
| 1.14.99.66 | more |
depletion of LSD1 by small interfering RNAs inhibits Cp basal transcription levels, and overexpression of LSD1 alters the cell cycle profile in p53-positive, but not p53-negative, HCT cells |
699898 |
| 1.14.99.66 | more |
hairpin RNA enzyme LSD1 knockdown, RNAi rescue experiments by expressing the human LSD1 cDNA |
-, 725541 |
| 1.14.99.66 | more |
knockdown of either TLX or LSD1 derepresses expression of the endogenous PTEN gene and inhibits cell proliferation of Y79 cells |
700154 |
