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EC Number
Protein Variants
Commentary
Reference
1.14.16.7
C187F
hydroxylation rate is reduced to less than 4% compared to the rate of wild-type enzyme
724321
1.14.16.7
C187F/T202G
hydroxylation rate is comparable to that of wild-type enzyme. Less than 8% of m-Tyr compared to p-Tyr is formed
724321
1.14.16.7
T202G
hydroxylation rate is comparable to that of wild-type enzyme. The ratio of product p-Tyr to m-Tyr is changed to 2:1 for the T202G mutant, which represents a 60-fold increase in the preference for p-Tyr over m-Tyr formation
724321
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