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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.15.29C429L the modification affect neither the binding nor the catalytic properties of the enzyme -, 717344
Display the word mapDisplay the reaction diagram Show all sequences 1.14.15.29W83Y mutation to the corresponding residue of isoform CYP125A4. Mutation reduces the size of the binding pocket, reducing the ability to bind 7alpha-hydroxylated substrates -, 744344
Display the word mapDisplay the reaction diagram Show all sequences 1.14.15.29Y83W mutation to the corresponding residue of isoform CYP125A3. Mutation increases the size of the binding pocket, increasing the ability to bind 7alpha-hydroxylated substrates. Enzyme shows activity toward 4-cholesten-3-one, albeit with sigmoidal kinetics -, 744344
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