EC Number   |
Protein Variants |
Reference |
|---|
   1.14.13.148 | D314A |
mutation decreases the activity significantly |
764744 |
| 1.14.13.148 | D314E |
enzymatic activity and the apparent KM toward NADPH are only slightly affected |
764744 |
| 1.14.13.148 | E158K |
the mutant shows reduced FMO3 activity |
718139 |
| 1.14.13.148 | E158K |
the mutation is associated with trimethylaminuria |
717652 |
| 1.14.13.148 | E24D |
the mutation impacts the structure of the Rossmann fold involved in FAD binding and does not alter FMO3 catalytic activity |
718139 |
| 1.14.13.148 | E305X |
the mutation is associated with trimethylaminuria |
717652 |
| 1.14.13.148 | E308G |
the mutant shows reduced FMO3 activity |
718139 |
| 1.14.13.148 | E308G |
the mutation is associated with trimethylaminuria |
717652 |
| 1.14.13.148 | H227A |
increase in apparent Km value |
764744 |
| 1.14.13.148 | K416N |
the mutation has minimal impact on either hydrophilicity or protein structure |
718139 |
