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EC Number
Protein Variants
Commentary
Reference
1.14.13.113
R204Q
the mutation leading to strongly decreased activity results in the uncoupling of nicotinamide adenine dinucleotide oxidation from uric acid hydroxylation
-
,
724386
1.14.13.113
R204Q
variant results in the uncoupling of nicotinamide adenine dinucleotide oxidation from uric acid hydroxylation. This suggests that Arg204 facilitates the deprotonation of uric acid, activating it for the oxygen transfer
-
,
724386
1.14.13.113
Y216F
about 10% of wild-type catalytic efficiency
-
,
724386
1.14.13.113
Y216F
the mutant shows decreased activity compared to the wild type enzyme
-
,
724386
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