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EC Number
Protein Variants
Commentary
Reference
1.13.11.63
A379V
naturally occuring polymorphism, the mutation causes 33% reduced BCMO1 activity compared to wild-type in vitro and 32% reduced conversion of beta-carotene after a pharmacological dose in female volunteers
713952
1.13.11.63
D52A
more than 50% loss of activity
674463
1.13.11.63
D52A/E140A
no enzymatic activity
674463
1.13.11.63
E140A
more than 50% loss of activity
674463
1.13.11.63
E314A
little reduction in enzymatic activity
674463
1.13.11.63
E405A
no enzymatic activity
674463
1.13.11.63
E450A
little reduction in enzymatic activity
674463
1.13.11.63
E457A
about 80% loss of activity
674463
1.13.11.63
E469A
about 50% decrease in activity, cells are bleached when left growing overnight
674463
1.13.11.63
H172A
no enzymatic activity
674463
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