EC Number   |
Protein Variants |
Reference |
|---|
    1.1.1.21 | C298A |
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme |
667807 |
| 1.1.1.21 | C298A/W219Y |
protein data bank: 1az1, structural analysis by molecular dynamics simulations |
657323 |
| 1.1.1.21 | C298A/W219Y |
site-directed mutagenesis, altered kinetics and thermodynamics in phenylacetic acid derivative inhibitor binding compared to the wild-type enzyme |
667913 |
| 1.1.1.21 | C298S |
similar sensitivity against Cu2+ as wild-type |
656089 |
| 1.1.1.21 | C298S |
treatment with peroxynitrite does not significantly affect the catalytic activity of C298S, and enzyme is insensitive to dimedone |
669455 |
| 1.1.1.21 | C303D |
introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors |
688417 |
| 1.1.1.21 | C303S |
insensitive to inactivation by CuCl2 |
656089 |
| 1.1.1.21 | C303S |
mutant is activated by peroxynitrite, and the peroxynitrite-modified protein is inhibited by dimedone |
669455 |
| 1.1.1.21 | F115Y |
stable and active |
685200 |
| 1.1.1.21 | F121P |
introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors |
688417 |
