EC Number   |
Protein Variants |
Reference |
|---|
   6.3.2.61 | C179A/Q180R/H362I |
the mutant no longer discriminates between heterogenous glutamylated brain microtubules and unmodified microtubules, as both the kcat and Km are similar with these substrates. The triple-mutant has strong preference for glutamylating an unmodified alpha1B peptide |
774687 |
| 6.3.2.61 | E439A |
inactive mutant of isoform TTLL6 |
763301 |
| 6.3.2.61 | K283A |
the mutation reduces activity to the background level |
774687 |
| 6.3.2.61 | K377A |
the mutation reduces activity to the background level |
774687 |
| 6.3.2.61 | more |
disruption of the TTLL1 and TTLL9 genes decrease the rates of cell multiplication and phagocytosis. Cells lacking both genes have fewer cortical microtubules and show defects in the maturation of basal bodies, in the TTLL1 and TTLL9 double knockout, a decrease in the levels of glutamylation on alpha-tubulin occurs, phenotype, overview |
692132 |
| 6.3.2.61 | more |
TTLL6_N705 is a stable and enzymatically active truncated protein version. Unlike the full-length enzyme TTLL6, the truncated protein does not localize to cilia |
751550 |
| 6.3.2.61 | Q180A |
he mutation decreases the enzyme activity by 64% compared to the wild type enzyme |
774687 |
