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Results 1 - 10 of 10
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75C745K mutation does not alter deconjugation rates in comparison with wild-type SENP7 715494
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75C979S site-directed mutagenesis 732566
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75C992A site-directed mutagenesis, inactive catalytic mutant 731715
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75F709W end point deconjugation reactions using di-SUMO2/3 or poly-SUMO2/3 reveales rates equivalent to or slightly greater than wild-type SENP7. Mutation results in a 2fold higher activity when di-SUMO2 deconjugation rates are measured 715494
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75more Depletion of SENP7 from NIH-3T3 cells by transfecting a plasmid encoding both a microRNA to downregulate SENP7 (miSENP7) and a GFP mRNA to enable identification of the transfected cells 732566
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75more enzyme knockout by siRNA in HeLa cells, complementation of knockdown with siRNA-resistant Flag-SENP7 731715
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75more knockdown strategy to deplete SENP7 from NIH-3T3 cells by transfecting a plasmid encoding both a microRNA to downregulate SENP7 and GFP mRNA to enable the identification of microRNA-expressing cells 731614
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75more lentivirus mediated SENP7 enzyme knockdown 731599
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75V713E mutation elicits 65-fold reduction in deconjugation rate compared to wild-type activity 715494
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B75V713E/C745K C745K substitution partially rescues defects observed for SENP7-V713E when present as a double point substitution (SENP7-V713E/C745K) 715494
Results 1 - 10 of 10