EC Number   |
Protein Variants |
Reference |
|---|
   3.4.22.64 | C254A |
enzymatically inactive |
754299 |
| 3.4.22.64 | C254A |
site-directed mutagenesis, OspC3 also co-immunoprecipitated with inactive p20- and-p10-unprocessed caspase-11 |
774702 |
| 3.4.22.64 | C254A |
site-directed mutagenesis, the catalytically inactive mutant shows highly reduced speck formation, catalytically deficient Casp11 lacks the ability to oligomerize autonomously |
770759 |
| 3.4.22.64 | C254A/D285A |
site-directed mutagenesis, an inactive, IDL-uncleavable Casp11 mutant |
770759 |
| 3.4.22.64 | C254A/K19E |
site-directed mutagenesis, mutations on the helix H1 2 located in the N-terminal side of CARD domain |
770172 |
| 3.4.22.64 | D285A |
mutation disrupts the processing site in the linker region between the large and small subunits of caspase-11 |
754299 |
| 3.4.22.64 | D285A |
site-directed mutagenesis, mutation of the IDL cleavage site, the non-cleavable mutant shows highly reduced speck formation |
770759 |
| 3.4.22.64 | K19E |
site-directed mutagenesis, the charge mutation positions in the middle of helix H1 2 |
770172 |
| 3.4.22.64 | K286Y/L287K/S288T |
site-directed mutagenesis |
774708 |
| 3.4.22.64 | K343T/A344P/S345R/I346A/H347K/S348A |
site-directed mutagenesis |
774708 |
