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Results 1 - 10 of 27 > >>
EC Number
Amino acid exchange
Commentary
Reference
C25A
has increased activity compared to the native VEGF-DDELTANDELTAC. Efficiently binds to the soluble receptor VEGFR-2/IgGFc. The C25A mutant behaves mainly as a monomeric protein on SDS-PAGE under reducing conditions but as a dimeric protein under non-reducing conditions. It induces VEGFR-2 Tyr-1175 phosphorylation
C25A/P43S
has biological activity comparable to that of the native protein in Ba/F3-VEGFR-2 cells
C25I
is mainly in a presumably covalently bound dimeric form
C25L
has increased activity compared to the native VEGF-DDELTANDELTAC, the C25L mutant is the most active mutant and is mainly in a presumably covalently bound dimeric form, has highest affinity to bind soluble receptor VEGFR-2/IgGFc. It induces VEGFR-2 Tyr-1175 phosphorylation
C25V
is mainly in a presumably covalently bound dimeric form
C44A
does not bind to the soluble receptor VEGFR-2/IgGFc
C53A
does not bind the soluble receptors VEGFR-2/IgGFc and VEGFR-3/IgGFc; does not bind to the soluble receptor VEGFR-2/IgGFc
G51C
can not induce cell survival, has increased dimer to monomer ratio
H133A
catalytically inactive
P43S
can not induce cell survival
Results 1 - 10 of 27 > >>