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EC Number
Amino acid exchange
Commentary
Reference
H169A
site-directed mutagenesis of the phosphatase sequence motif residue, the mutant shows 9% of wild-type enzyme DGPP phosphatase activity and no phosphatidic acid phosphatase activity
H169A
site-directed mutagenesis, the mutant enzyme shows 9% of wild-type enzyme activity
H223A
site-directed mutagenesis of the phosphatase sequence motif residue, the mutant shows 0.03% of wild-type enzyme DGPP phosphatase activity and no phosphatidic acid phosphatase activity
H223A
site-directed mutagenesis, the mutant enzyme shows 0.03% of wild-type enzyme activity
more
a gene pgpB mutant shows defect in phosphatidic acid phosphatase activity and also exhibits defects in lysophosphatidic acid phosphatase and phosphatidylglycerophosphate phosphatase activities
more
construction of a dpp1D mutant by deletion of the chromosomal copy of theDPP1 gene, the dpp1D mutant is viable and does not exhibit any obvious growth defects, the mutant is devoid of DGPP phosphatase activity and accumulates DGPP 4-fold compared to wild-type levels, phenotype, overview
more
construction of a mutant by deletions from the 5' end of the promoter indicated sequences responsible for enzyme expression, mutations in the three URSPDS elements within the DPP1 promoter abolish Gis1p-DNA interactions in vitro and abolish the regulation of DPP1 in vivo
more
dpp1DELTA mutants do not exhibit any dramatic phenotypes under a variety of growth conditions including fluctuations in zinc supplementation
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mutant strain CF20 is defective in gene pgpB and in phosphatidic acid phosphatase, lysophosphatidic acid phosphatase, and phosphatidylglycerophosphate phosphatase activities, while the overexpressing strain JM103 shows an enhancement of these activities, overview
more
the regulation pattern of DGPP phosphatase in mutants defective in plasma membrane, Zrt1p and Zrt2p, and vacuolar membrane, Zrt3p, zinc transporters indicates that the enzyme expression is sensitive to the cytoplasmic levels of zinc
Results 1 - 10 of 12 > >>