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Results 1 - 10 of 15 > >>
EC Number Protein Variants Commentary Reference
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18E294A complete loss of activity 721675
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18E294A site-directed mutagenesis, the mutant specific catalytic activity is 10000fold reduced compared to the wild-type enzyme, ligand bound crystal structure modeling 721675
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18E435A mutant protein is completely insoluble 721675
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18E435A site-directed mutagenesis, the mutant is completely insoluble, ligand bound crystal structure determination and analysis, the mutant crystallizes in a closed complex containing dethiaacetyl-CoA, which adopts an unusual curled conformation 721675
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18E435D activity similar to wild-type 721675
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18E435D site-directed mutagenesis, the mutant catalytic properties are nearly equivalent to those of the His6-tagged wild-type enzyme, ligand bound crystal structure modeling 721675
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18E435Q mutant protein is completely insoluble 721675
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18E435Q site-directed mutagenesis, the mutant is completely insoluble, ligand bound crystal structure modeling 721675
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18N347A large decrease in catalytic activity 721675
Show all pathways known for 2.8.3.18Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.18N347A site-directed mutagenesis, the mutant shows impaired catalytic activity, but the apparent affinities for all four substrates are largely unaffected, ligand bound crystal structure modeling 721675
Results 1 - 10 of 15 > >>