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Results 1 - 8 of 8
EC Number
Amino acid exchange
Commentary
Reference
C207S
using a complementation assay it is shown that mutant is required for 4-thiouridine synthesis but not for thiazole synthesis
C344S
using a complementation assay it is shown that mutant is required for 4-thiouridine synthesis but not for thiazole synthesis
C456S
using a complementation assay it is shown that mutant is required for 4-thiouridine synthesis and for thiazole synthesis
D189A
mutation eliminates in vivo function of the enzyme
D189A
using a complementation assay it is shown that mutant is required for 4-thiouridine synthesis but not for thiazole synthesis
K321M
mutation eliminates in vivo function of the enzyme
K321M
using a complementation assay it is shown that mutant is required for 4-thiouridine synthesis but not for thiazole synthesis
more
construction of two truncated forms of ThiI containing the N-terminal domain including NFLD and THUMP, and the C-terminal domain including the PP-loop and RLD domains, respectively. The N-domain can bind with both tRNAPhe and TPHE39A and recognizes the acceptor-stem region, whereas the C-domain cannot. The C-domain also affects RNA binding by its enthalpically favorable, but entropically unfavorable, contribution. The C-domain induces a conformation change in tRNAPhe
Results 1 - 8 of 8