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Results 1 - 10 of 10
EC Number
Amino acid exchange
Commentary
Reference
H146A
site-directed mutagenesis, the mutant is almost inactive
H226A
mutation in histidine residue in the HxGH motif of the C-terminal CT domain. Decrease in activity
H229A
mutation in histidine residue in the HxGH motif of the N-terminal CT domain. Activity similar to wild-type activity
H244A
inactive C-domain mutant, presence of the mutant reduces splice variant Pcyt2alpha homodimerization and activity
H244Y
inactive C-domain mutant, presence of the mutant reduces splice variant Pcyt2alpha homodimerization and activity
H35A
inactive N-domain mutant, presence of the mutant reduces splice variant Pcyt2alpha homodimerization and activity
H35A
mutation in histidine residue in the HxGH motif of the N-terminal CT domain. Complete loss of activity
H35Y
inactive N-domain mutant, presence of the mutant reduces splice variant Pcyt2alpha homodimerization and activity
H38A
mutation in histidine residue in the HxGH motif of the N-terminal CT domain. Strong decrease in activity
H422A
site-directed mutagenesis, the mutant shows increased kcat and Vmax with ethanolamine phosphate compared to the wild-type enzyme
Results 1 - 10 of 10