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Results 1 - 10 of 43 > >>
EC Number
Amino acid exchange
Commentary
Reference
D112E
muation decreases activity of the enzyme and does not interfere with H-type 1/H-type 2 acceptors
D125E
site-directed mutagenesis of FucT-V, the mutant activity is similar to the wild-type enzyme activity
D336A
fucosyltransferase III mutant enzyme shows reduced activity with a variety of acceptors, 40fold reduction in activity for Fucalpha(1,2)Galbeta(1,3)GlcNAc. 4fold reduction affinity for GDP-fucose. The single amino acid site Asp336 of FucT III and Ala349 of FucT V constitutes the only difference in the sequence of FucT III and V over the final 210 COOH-terminal amino acid residues, impacts the acceptor substrate profiles of FucT III and FuvT V
E111D
site-directed mutagenesis of FucT-VI, the mutant activity is similar to the wild-type enzyme activity
FT3dc
mutant where the cytoplasmic domain (Asp-2 to Trp-13) is deleted
I126V
site-directed mutagenesis of FucT-V, the mutant activity is similar to the wild-type enzyme activity
K73T
site-directed mutagenesis of FucT-VI, the mutant shows increased activity compared to the wild-type enzyme
K73T/E111D
site-directed mutagenesis of FucT-VI, the mutant shows increased activity compared to the wild-type enzyme
K73T/I75V/T87A
insertion mutagenesis of FucT-VI, the mutant shows altered substrate specificity compared to the wild-type enzyme
K73T/R110W
site-directed mutagenesis of FucT-VI, the mutant shows increased activity compared to the wild-type enzyme
Results 1 - 10 of 43 > >>