EC Number |
Protein Variants |
Reference |
---|
1.7.1.13 | C190A |
complete loss of activity |
724767 |
1.7.1.13 | D197N |
complete loss of activity |
724767 |
1.7.1.13 | E230Q |
about 4% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one |
724767 |
1.7.1.13 | F228W |
about 8% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one |
724767 |
1.7.1.13 | H229A |
about 15% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one |
724767 |
1.7.1.13 | Q89A |
poor activity |
724767 |
1.7.1.13 | Q89L |
poor activity |
724767 |
1.7.1.13 | S90A |
about 10% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one |
724767 |
1.7.1.13 | C99A |
mutant does not compromise enzyme activity. Contrary to wild-type, peroxide-induced inactivation is irreversible |
-, 742061 |
1.7.1.13 | C99S |
mutant does not compromise enzyme activity. Contrary to wild-type, peroxide-induced inactivation is irreversible |
-, 742061 |