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Results 1 - 10 of 11 > >>
EC Number
Amino acid exchange
Commentary
Reference
C190A
complete loss of activity
C190A
mutation in catalytic residue, no evidence of covalent binding of substrate preQ0. Mutant displays proton uptake
C99A
mutant does not compromise enzyme activity. Contrary to wild-type, peroxide-induced inactivation is irreversible
C99S
mutant does not compromise enzyme activity. Contrary to wild-type, peroxide-induced inactivation is irreversible
D197N
complete loss of activity
E230Q
about 4% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one
F228W
about 8% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one
H229A
about 15% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one
Q89A
poor activity
Q89L
poor activity
Results 1 - 10 of 11 > >>