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Amino acid exchange
improvement of the intracellular environment for enhancing L-arginine production of Corynebacterium glutamicum by inactivation of H2O2-forming flavin reductases and optimization of ATP supply. Construction of mutants of gene frd1, strain 5-5(frd1) and deletion strains 5-5DELTAfrd1 and 5-5DELTAfrd12. The extracellular H2O2 concentrations of mutants 5-5DELTAfrd1 and 5-5DELTAfrd12 are lower than that of the wild-type strain SYPA5-5, and the extracellular H2O2 concentrations of mutant 5-5(frd1) is increased compared to the wild-type. Flavin reductase activities in frd1 and frd2 overexpression and deletion strains with NADH and FAD, overview
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