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Results 1 - 10 of 19 > >>
EC Number
Amino acid exchange
Commentary
Reference
C62S
inactive mutant, no Fe-S cluster formation
C66S
inactive mutant, no Fe-S cluster formation
C69S
inactive mutant, no Fe-S cluster formation
C71S
inactive mutant, same Fe-S cluster formation as in wild-type HemN
E145A
appears colorless, the [4Fe-4S] cluster content is slightly reduced, no detectable S-adenosylmethionine cleavage, no detectable CPO activity
E145I
appears colorless, the [4Fe-4S] cluster content is slightly reduced, no detectable S-adenosylmethionine cleavage, no detectable CPO activity
F310A
is slightly yellow, the [4Fe-4S] cluster content is slightly reduced, cleaves only one S-adenosylmethionine molecule per molecule protein, residual CPO activity
F310L
is slightly yellow, the [4Fe-4S] cluster content is slightly reduced, cleaves only one S-adenosylmethionine molecule per molecule protein, no detectable CPO activity
F68L
mutant with 89% of wild-type activity
G111V/G113V
double mutation of Gly-111 and Gly-113, which are part of the potential GGGTP S-adenosyl-L-methionine binding motif, completely abolishes enzyme activity, reduced Fe-S cluster formation
Results 1 - 10 of 19 > >>