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Results 1 - 10 of 31 > >>
EC Number
Amino acid exchange
Commentary
Reference
C130S
the mutant forms charge-transfer complexes upon binding 3,4-dihydroxybenzoate, but the maximum of the broad charge-transfer bands is shifted to 610 nm
C130A
the mutant forms charge-transfer complexes upon binding 3,4-dihydroxybenzoate, but the maximum of the broad charge-transfer bands is shifted to 590 nm
C130A
the mutant enzyme exhibits binding affinities for dihydroorotate similar to that of the wild type enzyme, reduction is extremely slow compared to that of the wild type, the rate of reduction increases with pH showing no sign of a plateau
C130S
the mutant enzyme exhibits binding affinities for dihydroorotate similar to that of the wild type enzyme, reduction is extremely slow compared to that of the wild type, the rate of reduction increases with pH showing no sign of a plateau
Q7L
single nucleotide polymorphism due to missense polymorphism 19C>A, leading to amino acid substitution in the cationic N-terminal region of the polypeptide
N127A
reduced activity
V133T
reaction is somehow slower than for wild-type, binding of dihydroorotate is much weaker than with wild-type
L71F
reaction is somehow slower than for wild-type, binding of dihydroorotate is much tighter than with wild-type
L71F/V133T
reaction is drastically slower forwith wild-type, Kd for dihydroorotate is iabout eight-fold tighter than the wild-type
C130A
low activity with dihydroorotate, increasing activity above pH 8.0 with dihydrooxonate
Results 1 - 10 of 31 > >>