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Results 1 - 10 of 42 > >>
EC Number
Amino acid exchange
Commentary
Reference
D191A
mutation abrogates the ability of JBP1 to complement JBP1 null mutants
D215S
mutant proteins fail to restore the J-level in the JBP1 null trypanosomes to wild-type levels
D216N
site-directed mutagenesis, the mutant shows reduced activity with thymine and altered substrate specificity compared to the wild-type enzyme
D393A
site-directed mutagenesis, mutation inside the catalytic domain, procyclic cells expressing mutant versions of JBP2 inside the catalytic domain
D416A
site-directed mutagenesis, cells expressing the LtJBP2 mutant exhibits a serious growth defect
E122A
site-directed mutagenesis, the mutant shows reduced activity with thymine and altered substrate specificity compared to the wild-type enzyme
F292A
site-directed mutagenesis, the mutant shows highly reduced activity compared to the wild-type enzyme
H189A
mutation abrogates the ability of JBP1 to complement JBP1 null mutants
H189A/D191A
mutation abrogates the ability of JBP1 to complement JBP1 null mutants
H213S
mutant proteins fail to restore the J-level in the JBP1 null trypanosomes to wild-type levels
Results 1 - 10 of 42 > >>