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Results 1 - 10 of 17 > >>
EC Number Protein Variants Commentary Reference
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87R85V complete loss of activity with isocitrate, significant activity with 3-isopropylmalate, no effect on activity with homoisocitrate -, 656127
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87A80del site-directed mutagenesis, the mutant shows altered substrate specificity preferring isocitrate to homoisocitrate, it is unable to oxidize 3-isopropylmalate, the specificity is similar to the enzyme from Thermus thermophilus 660918
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87more modulation of the broad substrate specificity of the trifunctional enzyme through site-directed mutagenesis, overview 660918
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87R87T site-directed mutagenesis, the mutant oxidizes homoisocitrate, but not isocitrate and 3-isopropylmalate 660918
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87R87V site-directed mutagenesis, the mutant oxidizes homoisocitrate, but not isocitrate and 3-isopropylmalate 660918
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87V135M site-directed mutagenesis, tetramer-to-dimer structural transition enhances the activity with isocitrate 1.6fold 669109
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87more trex mutant allele, T to C exchange at nucleotide 251. Midgestation lethal mutant which displays craniofacial, limb, and organ abnormalities due to insufficient retinoic acid signaling 686950
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87K206M site-directed mutagenesis, the active site mutant shows about 2400fold reduced activity compared to the wild-type enzyme, the Km for HIc does not change significantly 696350
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87Y150F site-directed mutagenesis, the active site mutant shows about 680fold reduced activity compared to the wild-type enzyme, the Km for HIc does not change significantly 696350
Show all pathways known for 1.1.1.87Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.87D271N site-directed mutagenesis, mutation of a metal ion ligand and binding determinant for Mg2+, to N. The mutant enzyme shows a decrease of 520fold in V and V/Km_Mg2+, suggesting that the same step(s) limit the reaction at limiting and saturating MgHIc concentrations 739958
Results 1 - 10 of 17 > >>