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Results 1 - 10 of 41 > >>
EC Number
Amino acid exchange
Commentary
Reference
D107A
increase in Km, 2fold decrease in kcat
D107A
the mutant shows altered kinetics compared to the wild-type enzyme
F104A
increase in kcat
F104A
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
F104A
the mutant shows altered kinetics compared to the wild-type enzyme
F104A/I275A
shows no substrate inhibition accompanied by a weak affinity for productive salutaridine binding, kcat is almost 2fold higher compared with the wild-type
F104A/I275A
substitution of Phe104 in the substrate-binding pocket, and Ile275 under the flap domain, the mutant shows altered kinetics compared to the wild-type enzyme
I275A
increase in Km, shows an increase of velocity by a factor of 2.3
I275A
the mutant shows altered kinetics compared to the wild-type enzyme
I275V
the mutant shows altered kinetics compared to the wild-type enzyme
Results 1 - 10 of 41 > >>