EC Number   |
Protein Variants  |
Reference |
|---|
   3.4.21.47 | E207A |
mutation in proenzyme factor B. Mutation disrupts salt bridge R234-E207, with little effects on the cleavage of proenzyme factor B |
717849 |
| 3.4.21.47 | E301A |
mutation in the Bb component decreases sensitivity to DAF to 75% of the wild-type value |
652225 |
| 3.4.21.47 | E316A |
mutation in the Bb component decreases sensitivity to DAF to 71% of the wild-type value |
652225 |
| 3.4.21.47 | E379A |
mutation in the Bb component decreases sensitivity to DAF to 52% of the wild-type value, sensitivity to CR1 to 50% of the wild-type value |
652225 |
| 3.4.21.47 | E434A |
mutation in the Bb component decreases sensitivity to CR1 to 65% of the wild-type value |
652225 |
| 3.4.21.47 | E446V |
mutation in proenzyme factor B. Mutation disrupts salt bridge R234-E446 which partly stabilizes the complex C3bB(Mg2+) thereby inhibiting activation of the proenzyme |
717849 |
| 3.4.21.47 | F716A |
factor B mutation, severly reduces hemolytic activity |
36600 |
| 3.4.21.47 | K265A/K266A |
Mutation in the Bb component decreases sensitivity to DAF to 18% of the wild-type value, sensitivity to CR1 to 18% of the wild-type value and sensitivity to Factor H to 19% of the wild-type value |
652225 |
| 3.4.21.47 | K294A |
mutation in the Bb component decreases sensitivity to CR1 to 44% of the wild-type value |
652225 |
| 3.4.21.47 | M341A |
mutation in the Bb component decreases sensitivity to Factor H to 75% of the wild-type value |
652225 |
