EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.46 | S183A |
site-directed mutagenesis, structure analysis |
731071 |
| 3.4.21.46 | S81Y/T198S/S199W |
site-directed mutagenesis, the mutation causes steric hindrance of Trp199 resulting in pronounced rearrangement of the proteinase active-site region, structure analysis |
731071 |
| 3.4.21.46 | S94Y |
6fold increase in turnover number |
36587 |
| 3.4.21.46 | S94Y/T214/S215W |
the triple mutant has a turnover number that is 16fold higher than that of wild type factor D |
36587 |
| 3.4.21.46 | T214S/S215W |
more than 16fold incerease of the ratio of turnover number/KM-value |
36587 |
| 3.4.21.46 | T638G |
factor D deficient mutant |
668074 |
| 3.4.21.46 | T640C |
factor D deficient mutant |
668074 |
| 3.4.21.46 | V203D |
very low activity |
718398 |
