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EC Number
Protein Variants
Commentary
Reference
2.6.1.5
N17S
increase in Km-values, substantial decrease in kcat-values
660454
2.6.1.5
N54S
reduced enzymic activity
660454
2.6.1.5
R20A
increase in Km-values, substantial decrease in kcat-values
660454
2.6.1.5
R315K
retains enzymic activity
660454
2.6.1.5
R417Q
no enzymic activity
660454
2.6.1.5
R57A
no enzymic activity
660454
2.6.1.5
R57Q
no enzymic activity
660454
2.6.1.5
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switch of aspartate aminotransferase to use of tyrosine substrate by introduction of six mutations obtained by rational design and termed HEX plus mutation A293D or mutation I73V
660463
2.6.1.5
I249A
reduced catalytic activity
673540
2.6.1.5
C151Y
missense mutation leading to defective folding and likely alteration of the enzymatic activity
676025
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